Large sized injectors with low impedance are hard to tune correctly when using resistor packs as the injectors open too slowly making tuning at idle & cruising (low duty) very difficult.
The only way to fix it properly is to use peak & hold injector drivers (they are in the ECU) and no resistor packs.
This normally means changing ECU to a good aftermarket unit with P&H, or if running a megasquirt, some extra circuits.
The other way to get around the problem is to run staged injectors.
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