Should work. The seppos have been putting 20R heads on 22R's for a while. Wondering what the advantage is?? 22R head allows for the fitment of EFI or carby (see Hilux/Landcruiser 22Rs), where 21R restricts you to carby or a whole bunch of work to fit EFI.
You will need to check the combustion chamber shape, as differences here may require custom pistons, though I am fairly sure that the 21R and 22R combustion chambers are similar.
So why do you want to put a 21R head on a 22R??
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