Sam - mate im on a very similar path to you as we speak - im in the process of turboing my gen3 3sge which has a 10.5:1 compression ratio from factory - im currently running a microtech on it in n.a form anyway, so will be hoping for 11-12psi on 98 ron and 250 fwhp hopefully on stock internals
the key like most have said is tuning - given that higher cr will mean a bigger bang and higher pressures through the exhaust stroke earlier on in the range than compared with a lower static cr motor, it means you will definitely need a much more efficient turbo.
i know of someone who made 220 fwhp with a totally stock internalled silvertop 20v with a td04 turbo (innefficient), a very weak log manifold and a weak ass plenum which looked like a tim tam's packet - all with a microtech and (wait for it) 15psi of boost !!
a well thought out setup, with good tuning, enough fuel and adequate cooling (both intake temp cooling and motor cooling) will be pretty safe on today's fuel and standards.
id say make sure you have good injectors, an uprated fuel pump, fuel pressure regulator, good ring compression (ie compression test it before you turbo it to make sure your rings arent worn and therefore arent letting oil seep pass them and into the combustion chamber during the power stroke, which will effectively reduce your fuel's octane rating and increase the risk of detonation), a good aftermarket ecu with a reputable tuner, a functionable fan setup, oil cooling of some sort, and all the right tabs on things (boost gauge, oil pressure gauge, oil temp gauge etc)
goodluck with it mate - ill let you know how mine goes in a couple of weeks
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