64bit or 32bit Vista? If its 64bit, trying running it in compatibility mode (right click on the application (not the shortcut) and then Properties, then compatibility.
You can also right click on the program (again, not shortcut) and "Run As Administrator". That can help with older applications as well that are trying to access certain devices and directories etc.
Some more info here, http://groups.google.com/group/e-man...stall-e-manage
Notably:
Hope this helps**FOR MICROSOFT VISTA USERS**
You must perform the following steps PRIOR to beginning steps 11 and 12:
-A. Locate the Marketplace Software, LLC folder. The default location for this folder is:
C:\Program Files\Marketplace Software, LLC,\e-manage version 5.0
-B. Locate the "Live Update" folder within the "e-manage version 5.0" folder
-C. Locate the "e-manage Live Update.exe" icon within the "Live Update" folder
-D. Right click on the "e-manage Live Update.exe icon
-E. From the context menu, select "Run As Administrator"
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