My understanding with inserting larger Cams is that they increase in flow, valves opening further for longer allows more air in and quicker passing of the gas out, with timing you may need to advance it a little more so as to make sure that the valves are closed when the mixture is ignited.
By setting the timing you're really just setting where the piston is at the point of ignition, with the piston down more you are able to burn the entire mixture more effectively as it is not so dense, thus why advancing the engine will generally be a better ignition point and produce better combustion, power and/or torque.
Depending on what engine your using and the performance your after, I'd say about 10 degrees advanced would be good, however others on here have a far more better understanding than me so I'd be waiting for a few more posts before you take my advice to the bank.
EDIT*
Advancing tht timing ignites the fuel while the piston is on the compression stroke going up, the further advanced it is the earlier the spark and thus the further from the top the piston is.
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