If you have lost a main bearing, you can jack the car onto stands, drop the oil sump and remove the main caps to assess the damage. If you have damaged the crank journal though (the surface on the crank where the main bearing sits around) then you have to remove the crank and have it machined. Once machined you will need to buy oversized main bearings because once they machine material off of the crank the journal will become thinner so the oversized bearing will compensate for the extra clearance. I am unaware if there are any machining tools that operates can use to machine a crank while inside the engine. Pulling the crank out can be a big job because you need to free it of all components connected to the rotating assembly (connecting rods, flywheel, clutch, pressure plate, main pulleys(harmonic balancers).
You should pop your head under the car while you have someone rev the car until the knocking noise starts. Listen to whether it sounds like it is coming from near the sump (main bearings/connecting rods bearings) or if it sounds like its coming from the top of the engine (camshaft bearings perhaps).
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