Other stuff that I just remembered -
You want to run no more than about half an atmosphere vacuum in the engine, less in a road-ish engine or the seals will implode.
On the F1 engines, they have each 'V' section seperate from the others, and a scavenge pump for each of those. The reason being that they run a pretty good vacuum in them to reduce the aerodynamic effects on the crank. The volume of the V chamber doesn't change much, as one piston goes up and the other comes down.
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